Polygodial

Polygodial is chemical compound found in dorrigo pepper, mountain pepper, horopito, canelo, paracress, water-pepper, and Dendrodoris limbata.^{[1][2][3][4][5]}

Polygodial

Names
IUPAC name Drim-7-ene-11,12-dial
Systematic IUPAC name (1R,4aS,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarbaldehyde
Other names Poligodial; Tadeodal; Tadeonal
Identifiers
CAS Number	6754-20-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL254550 N
ChemSpider	65414 N
PubChem CID	72503
UNII	5FAF7T66M7 Y
InChI InChI=1S/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1 N Key: AZJUJOFIHHNCSV-KCQAQPDRSA-N N InChI=1/C15H22O2/c1-14(2)7-4-8-15(3)12(10-17)11(9-16)5-6-13(14)15/h5,9-10,12-13H,4,6-8H2,1-3H3/t12-,13-,15+/m0/s1 Key: AZJUJOFIHHNCSV-KCQAQPDRBV
SMILES CC1(CCC[C@]2([C@H]1CC=C([C@@H]2C=O)C=O)C)C
Properties
Chemical formula	C15H22O2
Molar mass	234.339 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Chemically it is a drimane-type sesquiterpene dialdehyde of formula C₁₅H₂₂O₂.

It elicits a warm and pungent flavour.

The in vitro biological activity of polygodial has been reported in the scientific literature to include antifungal and antimicrobial activities,^[6][7][8] antihyperalgesia,^[9] potent attachment-inhibitory activity,^[10] insect antifeedant activity,^[11] antinociception,^[12][13] vasorelaxing action in vessels of rabbit and guinea pig,^[14] anti-inflammatory and antiallergic activities.^[15][16][17]

Polygodial’s primary antifungal action is as a nonionic surfactant, disrupting the lipid-protein interface of integral proteins nonspecifically, denaturing their functional conformation. It is also likely that polygodial permeates by passive diffusion across the plasma membrane, and once inside the cells may react with a variety of intracellular compounds.^[18]

It is also an insecticide with antifeedant properties, which causes insects to starve.