Potassium channel opener

A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.

Examples

Some examples include:

Diazoxide^[1] vasodilator used for hypertension, smooth muscle relaxing activity
Minoxidil^[2] vasodilator used for hypertension, also used to treat hair loss
Nicorandil^[3] vasodilator used to treat angina
Pinacidil^[4]
Retigabine,^[5]^[6] an anticonvulsant
Flupirtine, analgesic with muscle relaxant and anticonvulsant properties

Class	Subclasses	Activators
Calcium-activated 6T & 1P	BK channel SK channel IK channel	^{[citation needed]} 1-EBIO NS309 CyPPA BK_Ca-specific: Flufenamic acid Meclofenamic acid Niflumic acid Nimesulide Rottlerin (mallotoxin) Tolfenamic acid
Inwardly rectifying 2T & 1P	ROMK (K_ir1.1)	^{[citation needed]} none
	GPCR regulated (K_ir3.x)	^{[citation needed]} GPCR agonists^{[example needed]} ML-297 (VU0456810)
	ATP-sensitive (K_ir6.x)	^{[citation needed]} Aprikalim Bimakalim Cromakalim Diazoxide Emakalim Levcromakalim Mazokalim Minoxidil Naminidil Nicorandil Pinacidil Rilmakalim Sarakalim
Tandem pore domain 4T & 2P	TWIK (TWIK-1, TWIK-2, KCNK7)^[7]^[8] TREK (TREK-1, TREK-2, TRAAK^[9])^[7]^[8] TASK (TASK-1, TASK-3, TASK-5)^[7]^[8] TALK (TASK-2,^[10] TALK-1, TALK-2)^[7]^[8] THIK (THIK-1, THIK-2)^[7]^[8] TRESK^[7]^[8]^[11]^[12]	^{[citation needed]} halothane^[13]^[14]^[15] Riluzole Arachidonic acid^[9]
Voltage-gated 6T & 1P	hERG (K_v11.1) KvLQT1 (K_v7.1)	KCNQ (K_v7)-specific: Flupirtine Retigabine (K_v7)^[16] XEN1101^[17]