Proteinase 3

PRTN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FUJ
Identifiers
Aliases	PRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDs	OMIM: 177020; MGI: 893580; HomoloGene: 120934; GeneCards: PRTN3; OMA:PRTN3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	848,175 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,719,008 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cells; ; spleen; ; blood; ; monocyte; ; right lung; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; upper lobe of left lung;
	Top expressed in
	body of femur; ; bone marrow; ; ankle joint; ; spleen; ; morula; ; white adipose tissue; ; yolk sac; ; neural tube; ; abdominal wall; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity; signaling receptor binding;
Cellular component	extracellular matrix; plasma membrane; extracellular exosome; cytosol; extracellular region; extracellular space; azurophil granule lumen; plasma membrane raft; membrane; membrane raft; collagen-containing extracellular matrix;
Biological process	collagen catabolic process; blood coagulation; negative regulation of phagocytosis; mature conventional dendritic cell differentiation; positive regulation of cell population proliferation; antimicrobial humoral response; neutrophil degranulation; proteolysis; membrane protein ectodomain proteolysis; positive regulation of GTPase activity; cell-cell junction maintenance; neutrophil extravasation; phagocytosis; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5657
	19152
	ENSG00000277804; ENSG00000196415
	ENSMUSG00000057729
	P24158
	Q61096
	NM_002777
	NM_011178
	NP_002768
	NP_035308
	Wikidata
View/Edit Human	View/Edit Mouse

Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.^[5]

Function

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.^[6]

References

External links

Proteinase+3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[5]

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Search

Proteinase 3

Contents

Function

References

Further reading

External links