RUNX1T1

RUNX1T1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WQ6, 2DJ8, 2H7B, 2KYG, 2OD1, 2ODD, 2PP4, 4JOL
Identifiers
Aliases	RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1
External IDs	OMIM: 133435; MGI: 104793; HomoloGene: 3801; GeneCards: RUNX1T1; OMA:RUNX1T1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	92,103,286 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	13,893,649 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sural nerve; ; buccal mucosa cell; ; tendon of biceps brachii; ; Brodmann area 23; ; Achilles tendon; ; paraflocculus of cerebellum; ; middle temporal gyrus; ; epithelium of colon; ; parietal pleura;
	Top expressed in
	Rostral migratory stream; ; secondary oocyte; ; zygote; ; internal carotid artery; ; genital tubercle; ; external carotid artery; ; olfactory tubercle; ; ascending aorta; ; mammillary body; ; lateral hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; transcription corepressor activity; metal ion binding;
Cellular component	nuclear matrix; nucleus; nucleoplasm;
Biological process	negative regulation of fat cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; generation of precursor metabolites and energy; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	862
	12395
	ENSG00000079102
	ENSMUSG00000006586
	Q06455
	Q61909
NM_001198625; NM_001198626; NM_001198627; NM_001198628; NM_001198629;
	NM_001198630; NM_001198631; NM_001198632; NM_001198633; NM_001198634; NM_001198679; NM_004349; NM_175634; NM_175635; NM_175636; NM_001395209
	NM_001111026; NM_001111027; NM_009822
NP_001185554; NP_001185555; NP_001185556; NP_001185557; NP_001185558;
	NP_001185559; NP_001185560; NP_001185561; NP_001185562; NP_001185563; NP_001185608; NP_004340; NP_783552; NP_783553; NP_783554; NP_783553.1; NP_783554.1
	NP_001104496; NP_001104497; NP_033952
	Wikidata
View/Edit Human	View/Edit Mouse

Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.^[7]

Interactions

RUNX1T1 has been shown to interact with:

Search

RUNX1T1

Contents

Function

Interactions

References

Further reading