Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation.[1][2]
Names | |
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IUPAC name N′-Cyclohexyl-N-(4-morpholinophenyl)-7H-purine-2,6-diamine | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.164.070 |
MeSH | C484369 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C21H27N7O | |
Molar mass | 393.495 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
It also has the potential to selectively induce cell death in cancer cells.[3]
Reversine is known to act as an antagonist of the adenosine A3 receptor. Reversine is a potent inhibitor of the mitotic kinase Mps1[4] and it is widely used to study the process of chromosome segregation.
References
External links
- Henry, Celia (January 5, 2004). "Cellular U-Turn". Chemical and Engineering News. 82 (1): 9. doi:10.1021/cen-v082n001.p009.
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