Ro 3-0422

Ro 3-0422
Names
	Preferred IUPAC name 3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate
	Other names 3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
Identifiers
CAS Number	5823-09-6;
3D model (JSmol)	Interactive image;
ChemSpider	174347;
PubChem CID	201356;
CompTox Dashboard (EPA)	DTXSID80206962 ;
	SMILES CCOP(=O)(OCC)Oc1cc2ccccc2[n+](c1)C.COS(=O)(=O)[O-];
Properties
Chemical formula	C15H22NO8PS
Molar mass	407.37 g·mol−1
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Extremely toxic
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	20 μg/kg (mice, intravenous)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD₅₀ is 20 μg/kg in mice.^[1] It is over 300 times more potent than neostigmine.^[2]

References

Names

Preferred IUPAC name 3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate
Other names 3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
Identifiers
CAS Number	5823-09-6
3D model (JSmol)	Interactive image
ChemSpider	174347
PubChem CID	201356
CompTox Dashboard (EPA)	DTXSID80206962
SMILES CCOP(=O)(OCC)Oc1cc2ccccc2[n+](c1)C.COS(=O)(=O)[O-]
Properties
Chemical formula	C₁₅H₂₂NO₈PS
Molar mass	407.37 g·mol⁻¹
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Extremely toxic
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	20 μg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references