SLC27A5

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.^[5][6][7]

SLC27A5
Identifiers
Aliases	SLC27A5, ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2, solute carrier family 27 member 5
External IDs	OMIM: 603314; MGI: 1347100; HomoloGene: 7596; GeneCards: SLC27A5; OMA:SLC27A5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 58,479,512 bp[1] End 58,512,413 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 12,722,273 bp[2] End 12,732,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver nucleus accumbens anterior cingulate cortex amygdala caudate nucleus putamen left testis right frontal lobe right testis C1 segment Top expressed in left lobe of liver gallbladder sexually immature organism morula embryo yolk sac blastocyst duodenum cerebellar cortex medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding fatty acid transmembrane transporter activity cholate-CoA ligase activity ligase activity catalytic activity very long-chain fatty acid-CoA ligase activity ATP binding long-chain fatty acid-CoA ligase activity protein-containing complex binding long-chain fatty acid transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of endoplasmic reticulum membrane basal plasma membrane endoplasmic reticulum protein-containing complex Biological process lipid metabolism very long-chain fatty acid metabolic process fatty acid transport fatty acid metabolic process ketone body biosynthetic process bile acid and bile salt transport long-chain fatty acid import across plasma membrane metabolism long-chain fatty acid metabolic process bile acid biosynthetic process triglyceride mobilization bile acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10998 26459 Ensembl ENSG00000083807 ENSMUSG00000030382 UniProt Q9Y2P5 Q4LDG0 RefSeq (mRNA) NM_012254 NM_001321196 NM_009512 RefSeq (protein) NP_001308125 NP_036386 NP_033538 Location (UCSC) Chr 19: 58.48 – 58.51 Mb Chr 7: 12.72 – 12.73 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.^[7]