Sarolaner

Sarolaner
Clinical data
Trade names	Simparica
Other names	PF-6450567
ATCvet code	QP53BE03 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: ℞-only;
Identifiers
	IUPAC name 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone;
CAS Number	1398609-39-6;
PubChem CID	73169092;
ChemSpider	31458198;
UNII	DM113FTW7F;
KEGG	D10668;
ChEMBL	ChEMBL3137302;
CompTox Dashboard (EPA)	DTXSID101336934 ;
ECHA InfoCard	100.234.000
Chemical and physical data
Formula	C23H18Cl2F4N2O5S
Molar mass	581.36 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12;
	InChI InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1; Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N;

Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs.^[3]^[4] It is also used off-label to control sarcoptic mange and demodectic mange.^[4]

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel.^[5] It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.^[6]

Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus^[7]), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.^[8]

References