T-1152 is a quaternary carbamate anticholinesterase. It is synthesized by reaction of m-dimethylaminophenol with methyl isocyanate, followed by quaternization with methyl iodide.[3] Since T-1152 is toxic by ingestion, it was patented as a rodenticide in 1932.[2]
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Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 270 μg/kg (subcutaneous, mice)[1] 115 μg/kg (intravenous, mice)[1] 260 μg/kg (subcutaneous, rabbits)[1] |
LDLo (lowest published) | 2.5 mg/kg (oral, mice)[2] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
The chloride and methylsulfate salt of T-1152 is T-1690 (TL-1226) and AR-13, respectively.[1]
See also
References
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