Telenzepine

Telenzepine
Clinical data
ATC code	None;
Identifiers
	IUPAC name 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one;
CAS Number	80880-90-6;
PubChem CID	5387;
ChemSpider	5194;
UNII	0990EG3K10;
ChEMBL	ChEMBL253978;
CompTox Dashboard (EPA)	DTXSID5045209 ;
Chemical and physical data
Formula	C19H22N4O2S
Molar mass	370.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(C)CCN1CC(=O)N2c3ccccc3NC(=O)c4csc(C)c42;
	InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25); Key:VSWPGAIWKHPTKX-UHFFFAOYSA-N;

Telenzepine is a thienobenzodiazepine acting as selective M₁ antimuscarinic. It is used in the treatment of peptic ulcers.^[1] Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex.^[2]

References

External links

Londong W, Londong V, Meierl A, Voderholzer U (July 1987). "Telenzepine is at least 25 times more potent than pirenzepine--a dose response and comparative secretory study in man". Gut. 28 (7): 888–95. doi:10.1136/gut.28.7.888. PMC 1433086. PMID 3653758.

[1]

[2]

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Telenzepine

See also

References

External links

Clinical data

ATC code	None
Identifiers
IUPAC name 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
CAS Number	80880-90-6
PubChem CID	5387
ChemSpider	5194
UNII	0990EG3K10
ChEMBL	ChEMBL253978
CompTox Dashboard (EPA)	DTXSID5045209
Chemical and physical data
Formula	C₁₉H₂₂N₄O₂S
Molar mass	370.47 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CN(C)CCN1CC(=O)N2c3ccccc3NC(=O)c4csc(C)c42
InChI InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25) Key:VSWPGAIWKHPTKX-UHFFFAOYSA-N