Tenilapine

Tenilapine
INN: tenilapine
Identifiers
	IUPAC name (2E)-[5-(4-Methyl-1-piperazinyl)-9H-bisthieno[3,4-b:3',4'-e]azepin-9-ylidene]acetonitrile;
CAS Number	82650-83-7 [PubChem];
PubChem CID	6450478;
ChemSpider	4953083;
UNII	D0U312O2BE;
ChEMBL	ChEMBL2105472;
CompTox Dashboard (EPA)	DTXSID201336787 ;
Chemical and physical data
Formula	C17H16N4S2
Molar mass	340.46 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCN(CC1)C2=NC3=CSC=C3/C(=C/C#N)/C4=CSC=C42;
	InChI InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+; Key:RVQVUMIXBGFJLZ-SWGQDTFXSA-N;

Tenilapine is an atypical antipsychotic which has never been marketed in the US.

Pharmacodynamics

Tenilapine has a relatively high affinity for the 5-HT_2A receptor, and relatively low (micromolar) affinities for dopamine receptors.

The ratio of D₂ to D₄ bonding is similar to that of clozapine.^[1] Like many other atypical antipsychotics, it is a potent 5-HT_2C antagonist.^[2]

Identifiers

IUPAC name (2E)-[5-(4-Methyl-1-piperazinyl)-9H-bisthieno[3,4-b:3',4'-e]azepin-9-ylidene]acetonitrile
CAS Number	82650-83-7^Y[PubChem]
PubChem CID	6450478
ChemSpider	4953083
UNII	D0U312O2BE
ChEMBL	ChEMBL2105472
CompTox Dashboard (EPA)	DTXSID201336787
Chemical and physical data
Formula	C₁₇H₁₆N₄S₂
Molar mass	340.46 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1CCN(CC1)C2=NC3=CSC=C3/C(=C/C#N)/C4=CSC=C42
InChI InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+ Key:RVQVUMIXBGFJLZ-SWGQDTFXSA-N