ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family (Pfam PF00005) have two such regions.[1][2][3][4][5][6]
| ABC transporter transmembrane region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ABC_membrane | ||||||||
| Pfam | PF00664 | ||||||||
| InterPro | IPR011527 | ||||||||
| PROSITE | PDOC00364 | ||||||||
| SCOP2 | 1pf4 / SCOPe / SUPFAM | ||||||||
| TCDB | 3.A.1 | ||||||||
| OPM superfamily | 17 | ||||||||
| OPM protein | 2hyd | ||||||||
| |||||||||
This family appears to correspond to ABC1 by TCDB classification.
Subfamilies
- Sulphate ABC transporter permease protein 2 InterPro: IPR005667
- Phosphate transport system permease protein 2 InterPro: IPR005672
- Phosphonate uptake transporter InterPro: IPR005769
- Nitrate transport permease InterPro: IPR005889
- NifC-like ABC-type porter InterPro: IPR006469
- Phosphate ABC transporter, permease protein PstC InterPro: IPR011864
- Molybdate ABC transporter, permease protein InterPro: IPR011867
- Nickel ABC transporter, permease subunit NikB InterPro: IPR014156
- Nickel ABC transporter, permease subunit NikC InterPro: IPR014157
- Ectoine/hydroxyectoine ABC transporter, permease protein EhuD InterPro: IPR014341
- Ectoine/hydroxyectoine ABC transporter, permease protein EhuC InterPro: IPR014342
Human proteins containing this domain
ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8;ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3;ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; TAP1; TAP2; TAPL;