Vesicular glutamate transporter 1

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5][6][7]

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA:SLC17A7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,429,401 bp[1] End 49,442,360 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,813,373 bp[2] End 44,825,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe superior frontal gyrus Brodmann area 10 frontal pole Region I of hippocampus proper middle temporal gyrus Brodmann area 46 dorsolateral prefrontal cortex orbitofrontal cortex Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus prefrontal cortex piriform cortex cerebellar cortex hippocampus proper primary motor cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inorganic phosphate transmembrane transporter activity sodium:inorganic phosphate symporter activity extracellularly glutamate-gated chloride channel activity symporter activity L-glutamate transmembrane transporter activity neurotransmitter transmembrane transporter activity Cellular component postsynapse integral component of membrane membrane synaptic vesicle plasma membrane synapse excitatory synapse synaptic vesicle membrane cerebellar mossy fiber presynaptic active zone cell junction intracellular organelle neuron projection clathrin-sculpted glutamate transport vesicle membrane cytoplasmic vesicle integral component of synaptic vesicle membrane Biological process phosphate ion transport synaptic transmission, glutamatergic sodium-dependent phosphate transport sodium ion transport chloride transmembrane transport ion transport glutamate secretion synaptic vesicle lumen acidification brain development long-term memory excitatory postsynaptic potential neurotransmitter transport neural retina development L-glutamate import sequestering of neurotransmitter sodium ion transmembrane transport transmembrane transport chemical synaptic transmission neurotransmitter loading into synaptic vesicle L-glutamate transmembrane transport regulation of synaptic vesicle endocytosis regulation of synapse structure or activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57030 72961 Ensembl ENSG00000104888 ENSMUSG00000070570 UniProt Q9P2U7 Q3TXX4 RefSeq (mRNA) NM_020309 NM_182993 RefSeq (protein) NP_064705 NP_892038 Location (UCSC) Chr 19: 49.43 – 49.44 Mb Chr 7: 44.81 – 44.83 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[7]