Zem can refer to:
- Zem, a character from Crash Bandicoot
- Nkong-Zem, a town and commune in Cameroon
- Roschdy Zem (born 1965), a French actor and filmmaker of Moroccan descent
- ZEM, a Portuguese Pop-Rock band
- Zem (mattress), a character in The Hitchhiker's Guide to the Galaxy by Douglas Adams
- ZEM, the IATA code for Eastmain River Airport, Quebec, Canada