May 19 – The Tariff of 1828 is enacted. Critics name it the 'Tariff of Abominations' because they see it as unfairly protective of northern industry to the detriment of the southern economy.
October 27 – Gold is discovered by Benjamin Parks in or near Cherokee First Nation land in Hall County - later reorganized into Lumpkin County - in, Georgia.
December 20 – The Georgia state legislature charters the Medical Academy of Georgia, which becomes the Medical College of Georgia, and authorizes it to award a Bachelor of Medicine degree, making it the 13th oldest U.S. medical school and the 6th public medical school to be established.