Wendy Turnbull and Marty Riessen were the defending champions but lost in the first round to Wendy White and Mike Bauer.
| Mixed doubles | |
|---|---|
| 1981 US Open | |
| Champions |  Anne Smith  Kevin Curren |
| Runners-up | JoAnne Russell Steve Denton |
| Score | 6–4, 7–6(7–4) |
Anne Smith and Kevin Curren won in the final 6–4, 7–6(7–4) against JoAnne Russell and Steve Denton.
Seeds
Champion seeds are indicated in bold text while text in italics indicates the round in which those seeds were eliminated.
Betty Stöve / 
Frew McMillan (second round)
Wendy Turnbull / 
Marty Riessen (first round)- Anne Smith / Kevin Curren (champions)
- JoAnne Russell / Steve Denton (final)
Virginia Ruzici / Ilie Năstase (quarterfinals)- Pam Teeguarden /
Heinz Günthardt (quarterfinals) - Mary Lou Piatek / Ross Case (quarterfinals)
Bettina Bunge / Dick Stockton (semifinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Final
| Final | ||||||
| 4 | JoAnne Russell Steve Denton | 4 | 64 | |||
| 3 | Anne Smith Kevin Curren | 6 | 77 | |||
Top half
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 |  B Stöve F McMillan | 6 | 3 | 7 | |||||||||||||||||||||||
| S Mascarin S Davis | 2 | 6 | 5 | 1 | B Stöve F McMillan | 1 | 3 | ||||||||||||||||||||
| P Smith M Purcell | 7 | 3 | 6 | P Smith M Purcell | 6 | 6 | |||||||||||||||||||||
| B Nagelsen R Meyer | 6 | 6 | 3 | P Smith M Purcell | 6 | 3 | 6 | ||||||||||||||||||||
| K Rinaldi V Van Patten | 3 | 7 | 7 | 7 | M L Piatek R Case | 3 | 6 | 4 | |||||||||||||||||||
| D Desfor G Hardie | 6 | 6 | 6 | K Rinaldi V Van Patten | 4 | 6 | |||||||||||||||||||||
| N Yeargin J Benson | 3 | 5 | 7 | M L Piatek R Case | 6 | 7 | |||||||||||||||||||||
| 7 | M L Piatek R Case | 6 | 7 | P Smith M Purcell | 6 | 4 | |||||||||||||||||||||
| 4 | J Russell S Denton | 6 | 7 | 4 | J Russell S Denton | 7 | 6 | ||||||||||||||||||||
| D Fromholtz M Edmondson | 1 | 6 | 4 | J Russell S Denton | 6 | 6 | |||||||||||||||||||||
| M Kremer T Buford | 6 | 6 | M Kremer T Buford | 1 | 4 | ||||||||||||||||||||||
 E Pfaff R Fagel | 4 | 3 | 4 | J Russell S Denton | 6 | 6 | |||||||||||||||||||||
I Kloss J Fillol | w/o | 6 | P Teeguarden H Günthardt | 4 | 4 | ||||||||||||||||||||||
| S Walsh D Ralston | I Kloss H Günthardt | 6 | 5 | ||||||||||||||||||||||||
| D Morrison M Mitchell | 4 | 6 | 1 | 6 | P Teeguarden H Günthardt | 7 | 7 | ||||||||||||||||||||
| 6 | P Teeguarden H Günthardt | 6 | 2 | 6 | |||||||||||||||||||||||
Bottom half
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 |  V Ruzici I Năstase | 6 | 6 | ||||||||||||||||||||||||
| L Forood K Kerns | 3 | 4 | 5 | V Ruzici I Năstase | 6 | 3 | 6 | ||||||||||||||||||||
| A Kiyomura M Estep | 6 | 6 | A Kiyomura M Estep | 4 | 6 | 4 | |||||||||||||||||||||
 C Newton M Doyle | 4 | 1 | 5 | V Ruzici I Năstase | 7 | 2 | 6 | ||||||||||||||||||||
| R Fairbank P Cramer | 3 | 6 | 6 | 3 | A Smith K Curren | 5 | 6 | 7 | |||||||||||||||||||
| S Acker C Leeds | 6 | 3 | 1 | R Fairbank P Cramer | 2 | 3 | |||||||||||||||||||||
| B Jordan J Delaney | 6 | 4 | 3 | A Smith K Curren | 6 | 6 | |||||||||||||||||||||
| 3 | A Smith K Curren | 7 | 6 | 3 | A Smith K Curren | 6 | 6 | ||||||||||||||||||||
| 8 | B Bunge D Stockton | 7 | 6 | 8 | B Bunge D Stockton | 4 | 4 | ||||||||||||||||||||
| ALT | S Margolin M Margolin | 5 | 0 | 8 | B Bunge D Stockton | 6 | 6 | ||||||||||||||||||||
| L Allen G Fritz | 7 | 5 | 7 | L Allen G Fritz | 3 | 2 | |||||||||||||||||||||
 A Hobbs E Fromm | 5 | 7 | 6 | 8 | B Bunge D Stockton | 6 | 6 | ||||||||||||||||||||
| P Whytcross C Letcher | 7 | 4 | 6 | W White M Bauer | 4 | 4 | |||||||||||||||||||||
| L Romanov S Krulevitz | 5 | 6 | 4 | P Whytcross C Letcher | 3 | 4 | |||||||||||||||||||||
| W White M Bauer | 4 | 6 | 7 | W White M Bauer | 6 | 6 | |||||||||||||||||||||
| 2 | W Turnbull M Riessen | 6 | 3 | 6 | |||||||||||||||||||||||
References
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