Maria Sanchez and Fanny Stollár were the defending champions from when the tournament was last held in 2019,[1] but they lost in the semifinals to Ellen Perez and Astra Sharma.
| Doubles | |
|---|---|
| 2021 Abierto Zapopan | |
| Champions |  Ellen Perez Astra Sharma |
| Runners-up |  Desirae Krawczyk Giuliana Olmos |
| Score | 6–4, 6–4 |
Perez and Sharma went on to win the title, defeating Desirae Krawczyk and Giuliana Olmos in the final, 6–4, 6–4.
Seeds
Desirae Krawczyk / 
Giuliana Olmos (final)- Caroline Dolehide / Vania King (quarterfinals)
Ellen Perez / Astra Sharma (champions)
Mihaela Buzărnescu / 
Anna-Lena Friedsam (quarterfinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | D Krawczyk G Olmos | 7 | 6 | ||||||||||||||||||||||||
 I Bara  D Jakupović | 5 | 1 | 1 | D Krawczyk G Olmos | 6 | 4 | [10] | ||||||||||||||||||||
 L Arruabarrena  K Piter | 7 | 4 | [8] |  N Podoroska S Sorribes Tormo | 4 | 6 | [7] | ||||||||||||||||||||
| N Podoroska S Sorribes Tormo | 5 | 6 | [10] | 1 | D Krawczyk G Olmos | 6 | 2 | ||||||||||||||||||||
| 4 | M Buzărnescu  A-L Friedsam | 6 | 6 | A Bolsova  D Kovinić | 2 | 0r | |||||||||||||||||||||
 A Blinkova  K Kučová | 4 | 2 | 4 | M Buzărnescu A-L Friedsam | 3 | 3 | |||||||||||||||||||||
| A Bolsova D Kovinić | 6 | 65 | [10] | A Bolsova D Kovinić | 6 | 6 | |||||||||||||||||||||
 E Hozumi M Kato | 2 | 77 | [3] | 1 | D Krawczyk G Olmos | 4 | 4 | ||||||||||||||||||||
| WC |  E Bouchard C Vandeweghe | 79 | 6 | 3 | E Perez A Sharma | 6 | 6 | ||||||||||||||||||||
P Kania-Choduń  A Raina | 67 | 2 | WC | E Bouchard C Vandeweghe | 4 | 4 | |||||||||||||||||||||
| WC | LA Fernandez R Zarazúa | 6 | 1 | [7] | 3 | E Perez A Sharma | 6 | 6 | |||||||||||||||||||
| 3 | E Perez A Sharma | 4 | 6 | [10] | 3 | E Perez A Sharma | 4 | 7 | [10] | ||||||||||||||||||
M Sanchez  F Stollár | 77 | 5 | [10] | M Sanchez F Stollár | 6 | 5 | [7] | ||||||||||||||||||||
| Alt | I Neel T Zidanšek | 61 | 7 | [4] | M Sanchez F Stollár | 6 | 3 | [10] | |||||||||||||||||||
| K Juvan A Kalinskaya | 4 | 4 | 2 | C Dolehide V King | 1 | 6 | [7] | ||||||||||||||||||||
| 2 | C Dolehide V King | 6 | 6 | ||||||||||||||||||||||||