Haloprogesterone, sold under the brand name Prohalone, is a progestin medication which was previously marketed by Ayerst but is now no longer available.[1][2][3]
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| Trade names | Prohalone |
| Other names | Aloprogesterone; 6α-Fluoro-17α-bromoprogesterone; 6α-Fluoro-17α-bromopregn-4-ene-3,20-dione |
| Routes of administration | By mouth |
| Drug class | Progestogen; Progestin |
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| Formula | C21H28BrFO2 |
| Molar mass | 411.355 g·mol−1 |
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Chemistry
Haloprogesterone, also known as 6α-fluoro-17α-bromoprogesterone or as 6α-fluoro-17α-bromopregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of progesterone.[1] It is specifically a derivative of 17α-bromoprogesterone and is similar structurally to medrogestone (6-dehydro-6,17α-dimethylprogesterone), medroxyprogesterone acetate (6α-methyl-17α-acetoxyprogesterone), and various other progestins derived from progesterone.[1]
Synthesis
Chemical syntheses of haloprogesterone have been published.[4]
History
Haloprogesterone was synthesized in 1960 and was introduced for medical use by 1961.[1][5][6]
Society and culture
Generic names
Haloprogesterone is the generic name of the drug and its INN and USAN.[1][3]
Brand names
Haloprogesterone was marketed under the brand name Prohalone.[1]