NEFM

NEFM
Identifiers
Aliases	NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium, neurofilament medium chain
External IDs	OMIM: 162250 HomoloGene: 38041 GeneCards: NEFM
Gene location (Human)
Chr.	Chromosome 8 (human)
End	24,919,098 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; pons; ; middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; superior vestibular nucleus; ; frontal pole; ; external globus pallidus; ; parietal lobe; ; Brodmann area 10;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	neurofibrillary tangle; axon; intermediate filament; neurofilament; intermediate filament cytoskeleton;
Biological process	neurofilament bundle assembly; axon development;
	Sources:Amigo / QuickGO
Orthologs
	4741
	n/a
	ENSG00000104722
	n/a
	P07197
	n/a
	NM_005382; NM_001105541
	n/a
	NP_001099011; NP_005373
	n/a
	Wikidata
View/Edit Human

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.^[3]^[4]

Function

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the exoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.^[4]

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NEFM

Function

References

Further reading