NUPR1

Nuclear protein 1 is a protein that in humans is encoded by the NUPR1 gene.^[5][6][7][8]

NUPR1
Identifiers
Aliases	NUPR1, COM1, P8, nuclear protein 1, transcriptional regulator
External IDs	OMIM: 614812 MGI: 1891834 HomoloGene: 8229 GeneCards: NUPR1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 28,532,708 bp[1] End 28,539,008 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,222,421 bp[2] End 126,230,033 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland body of pancreas gastric mucosa skin of abdomen right lung prostate right lobe of liver left coronary artery subcutaneous adipose tissue Top expressed in submandibular gland lacrimal gland calvaria crypt of lieberkuhn of small intestine ascending aorta epithelium of stomach parotid gland pyloric antrum aortic valve right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin binding DNA binding protein binding transcription coactivator activity acetyltransferase activator activity Cellular component nucleus cytosol protein-DNA complex cytoplasm perinuclear region of cytoplasm Biological process skeletal muscle cell differentiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of cell cycle male gonad development regulation of transcription, DNA-templated acute inflammatory response negative regulation of fibroblast proliferation regulation of female gonad development response to toxic substance transcription, DNA-templated protein acetylation positive regulation of protein modification process positive regulation of apoptotic process regulation of transcription by RNA polymerase II cell population proliferation protein-containing complex assembly negative regulation of cell population proliferation positive regulation of catalytic activity positive regulation of proteasomal protein catabolic process positive regulation of nucleic acid-templated transcription regulation of autophagy negative regulation of autophagy negative regulation of cardiac muscle cell apoptotic process negative regulation of apoptotic process negative regulation of DNA-binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of glycolytic process negative regulation of epithelial cell proliferation negative regulation of programmed necrotic cell death positive regulation of neuroinflammatory response negative regulation of autophagosome assembly positive regulation of oxidative phosphorylation negative regulation of epithelial cell apoptotic process negative regulation of type B pancreatic cell proliferation regulation of response to endoplasmic reticulum stress positive regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26471 56312 Ensembl ENSG00000176046 ENSMUSG00000030717 UniProt O60356 Q9WTK0 RefSeq (mRNA) NM_012385 NM_001042483 NM_019738 RefSeq (protein) NP_001035948 NP_036517 NP_062712 Location (UCSC) Chr 16: 28.53 – 28.54 Mb Chr 7: 126.22 – 126.23 Mb PubMed search [3] [4]
Wikidata
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