PEX14

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Peroxisomal membrane anchor protein (Pex14p) conserved region
Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
Symbol	Pex14_N
Pfam	PF04695
InterPro	IPR006785
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

PEX14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W84, 2W85, 4BXU
Identifiers
Aliases	PEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
External IDs	OMIM: 601791 MGI: 1927868 HomoloGene: 37936 GeneCards: PEX14
Gene location (Human)
Chr.	Chromosome 1 (human)
End	10,630,758 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,184,333 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; parotid gland; ; right lobe of liver; ; pancreatic ductal cell; ; prefrontal cortex; ; urinary bladder; ; endothelial cell; ; oocyte; ; prostate; ; retinal pigment epithelium;
	Top expressed in
	otic placode; ; saccule; ; entorhinal cortex; ; yolk sac; ; proximal tubule; ; tongue; ; brown adipose tissue; ; secondary oocyte; ; lip; ; pons;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; protein N-terminus binding; microtubule binding; protein binding; beta-tubulin binding; signaling receptor binding;
Cellular component	integral component of membrane; membrane; peroxisomal membrane; peroxisome; intracellular anatomical structure; nucleus; fibrillar center; peroxisomal importomer complex; protein-containing complex;
Biological process	peroxisome organization; negative regulation of protein homotetramerization; peroxisome transport along microtubule; negative regulation of protein binding; negative regulation of DNA-binding transcription factor activity; microtubule anchoring; protein import into peroxisome matrix; protein import into peroxisome matrix, substrate release; protein transport; negative regulation of transcription, DNA-templated; protein homooligomerization; protein import into peroxisome matrix, translocation; transport; protein targeting to peroxisome; protein import into peroxisome matrix, docking; protein ubiquitination; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	5195
	56273
	ENSG00000142655
	ENSMUSG00000028975
	O75381
	Q9R0A0
	NM_004565
	NM_019781
	NP_004556
	NP_062755
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.^[5]^[6]

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.^[6]

Interactions

PEX14 has been shown to interact with

PEX5,^[7]^[8]^[9]^[10]
PEX7,^[10] and
PEX13.^[7]

References

External links

GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
Eukaryotic Linear Motif resource motif class TRG_PEX_1
Eukaryotic Linear Motif resource motif class TRG_PEX_2
Overview of all the structural information available in the PDB for UniProt: O75381 (Peroxisomal membrane protein PEX14) at the PDBe-KB.

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Search

PEX14

Contents

Function

Interactions

References

Further reading

External links