PEX14

PEX14
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2W84, 2W85, 4BXU
Dynodwyr
Cyfenwau	PEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
Dynodwyr allanol	OMIM: 601791 HomoloGene: 37936 GeneCards: PEX14
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001106 transcription corepressor activity; • protein N-terminus binding; • microtubule binding; • GO:0001948, GO:0016582 protein binding; • beta-tubulin binding; • signaling receptor binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • peroxisomal membrane; • peroxisome; • intracellular anatomical structure; • cnewyllyn cell; • fibrillar center; • peroxisomal importomer complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• peroxisome organization; • negative regulation of protein homotetramerization; • peroxisome transport along microtubule; • negative regulation of protein binding; • negative regulation of DNA-binding transcription factor activity; • microtubule anchoring; • protein import into peroxisome matrix; • protein import into peroxisome matrix, substrate release; • protein transport; • GO:0045996 negative regulation of transcription, DNA-templated; • protein homooligomerization; • protein import into peroxisome matrix, translocation; • GO:0015915 transport; • protein targeting to peroxisome; • protein import into peroxisome matrix, docking; • protein ubiquitination; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	5195
	n/a
	ENSG00000142655
	n/a
	O75381
	n/a
	NM_004565
	n/a
	NP_004556
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PEX14 yw PEX14 a elwir hefyd yn Peroxisomal biogenesis factor 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PEX14.

NAPP2
PBD13A
Pex14p
dJ734G22.2

Llyfryddiaeth

"Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. ". Hum Mutat. 2004. PMID 15146459.
"Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction. ". Biochim Biophys Acta. 2002. PMID 12488033.
"First Japanese case of Zellweger syndrome with a mutation in PEX14. ". Pediatr Int. 2015. PMID 26627464.
"Identification of a novel PEX14 mutation in Zellweger syndrome. ". J Med Genet. 2008. PMID 18285423.
"A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.". J Biol Chem. 2014. PMID 24235149.

Cyfeiriadau

[2]

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