Clamoxyquine

Clamoxyquine (INN) or clamoxyquin (former BAN), as the pamoate or hydrochloride salt, is an antiamebic and antidiarrheal drug.

Clamoxyquine
Clinical data
ATC code
  • none
Identifiers
  • 5-Chloro-7-({[3-(diethylamino)propyl]amino}methyl)quinolin-8-ol
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H24ClN3O
Molar mass321.85 g·mol−1
3D model (JSmol)
  • Clc1cc(c(O)c2ncccc12)CNCCCN(CC)CC

It has been used as a veterinary medicine to treat salmonids for infection with the myxozoan parasite Myxobolus cerebralis.

Synthesis

Antimalarial activity also predominates in a quinoline that bears a diaminoalkyl side chain at a rather different position from the other agents noted.

Clamoxyquin synthesis:[1]

Thus, Mannich condensation of the hydroxyquinoline (1) with formaldehyde and N,N-diethylpropylenediamine affords clamoxyquin (2).

References

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